Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates
Andrew C. Marshall, Jerry Cummins, Simon Kobelke, Tianyi Zhu, Jocelyn Widagdo, Victor Anggono, Anthony A. Hyman, Archa H. Fox, Charles S. Bond, Mihwa Lee
This study identifies distinct roles of low-complexity regions in SFPQ for biomolecular condensate formation, showing the C-terminal region drives condensation while the N-terminal region inhibits it.
Journal of Molecular Biology · Nov 10, 2023Peer-reviewedMolecular Biology