Mariajose Metcalfe

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injury

This study investigates the effects of AAV-mediated CSPG digestion and PTEN knockdown on functional recovery after cervical spinal cord injury, finding that CSPG degradation alone or combined with PTEN suppression impairs motor function.

PTEN deletion in spinal pathways via retrograde transduction with AAV-rg enhances forelimb motor recovery after cervical spinal cord injury; sex differences and late-onset pathophysiologies

This study uses AAV-rg/Cre to delete PTEN in spinal pathway cells after SCI, improving forelimb motor recovery but causing late-onset pathophysiologies in mice.

Elevation of NAD+ by nicotinamide riboside spares spinal cord tissue from injury and promotes locomotor recovery

This study shows that nicotinamide riboside (NR) increases NAD+ levels in the injured spinal cord, protecting tissue and improving locomotor recovery in rats.

A modular platform for bioluminescent RNA tracking

This paper introduces a bioluminescent platform for tracking RNA in vivo, demonstrating single-copy detection and robust imaging in cells and live animals.

Rostro-caudal specificity of corticospinal tract projections in mice

The paper investigates rostro-caudal specificity of corticospinal tract projections in mice using retrograde labeling and injection techniques, revealing distinct termination patterns in different spinal cord regions.