Maayan R. Agam

CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity

TN-783, a CNS-penetrant NLRP3 inhibitor, induces sustained weight loss and reverses hypothalamic inflammation in diet-induced obese mice.

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction

This study shows the PD-risk GBA1 variant E326K reduces lysosomal GCase activity by disrupting LIMP2 interaction and causes lysosomal and mitochondrial dysfunction.

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

This paper uses VINE-seq to create a vascular transcriptomic atlas in Alzheimer's disease, revealing transcriptional changes in vascular cells and identifying angiopoietin signaling as a key dysregulated pathway.

LRRK2 Kinase Activity Regulates Parkinson's Disease-Relevant Lipids at the Lysosome

This study shows that LRRK2 kinase activity affects BMP and GSL levels in lysosomes, linking lysosomal dysfunction to Parkinson's disease through changes in GCase activity and BMP accumulation.

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.