Ahlam N. Qerqez

The paper identifies antibodies that block PlGF or VEGFA interactions with NRP1, showing anti-proliferative effects in cancer cells and reduced angiogenesis.

This paper engineers IgG1 antibodies with modified Fc domains to resist viral Fc receptor binding, enhancing NK cell activation and reducing HCMV spread in infected cells.

This study shows the PD-risk GBA1 variant E326K reduces lysosomal GCase activity by disrupting LIMP2 interaction and causes lysosomal and mitochondrial dysfunction.

This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.