Author

Jennifer E. Kung

Denali Therapeutics (United States)ORCID 0000-0002-6784-7076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Ahlam N. QerqeziD· 1 shared Alexis L. RohouiD· 1 shared Anastasia G. HenryiD· 1 shared Angela Oh· 1 shared Ann Hong NguyeniD· 1 shared Annie ArguelloiD· 1 shared Cathal S. MahoniD· 1 shared Christine C. JaoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Ahlam N. QerqezORCID

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2 papers

Recent·Most cited

Disulfide constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM

Jennifer E. Kung, Matthew Camp Johnson, Dimitry Tegunov, Christine C. Jao, Ping Wu, Angela Oh, May H. Lin, Jose M. Daria, Christopher M. Koth, Christopher P. Arthur, Alexis L. Rohou, Jawahar Sudhamsu

This paper introduces Rigid-Fabs, disulfide-constrained antibody fragments that enable high-resolution cryo-EM structures of small proteins by overcoming size limitations.

Nature Communications · Sep 30, 2025Peer-reviewedBiophysics

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction

Oliver B. Davis, Jennifer E. Kung, Sonnet S. Davis, Rajarshi Ghosh, Shan V. Andrews, Neal S. Gould, Jillian H. Kluss, Elliot R. Thomsen, Maayan R. Agam, John P. Coan, Michael T. Maloney, Ann Hong Nguyen, Hoang Ngan Nguyen, Nicholas E. Propson, Edwin I. Lozano, , Anastasia G. Henry

This study shows the PD-risk GBA1 variant E326K reduces lysosomal GCase activity by disrupting LIMP2 interaction and causes lysosomal and mitochondrial dysfunction.

bioRxiv · Aug 28, 2025 · PreprintCell Biology

Jennifer E. Kung · henhao