Author
Leiden UniversityORCID 0000-0002-5034-5766Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Mirela Andronescu, Alexander Adrian-Hamazaki, Damian Yap…·Samuel A. J. R. Aparicio
This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.
Hoa Tran, Gurdeep Singh, Hakwoo Lee…·Samuel A. J. R. Aparicio
This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.
Marc J. Williams, Michael U. J. Oliphant, Vinci Au…·Samuel A. J. R. Aparicio
The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.
Payam Emami Khoonsari, Pablo A Moreno, Sven Bergmann…·Ola Spjuth
The paper introduces a microservices-based framework for scalable data analysis, validated in metabolomics, enabling dynamic scaling and integration of software tools.
Kristian Peters, James Bradbury, Sven Bergmann…·Christoph Steinbeck
PhenoMeNal provides a cloud-based platform for metabolomics data analysis, integrating tools and workflows to enable reproducible and scalable research.