Ian M. Sudbery

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

The paper modifies Seurat v4 to distinguish between G2 and mitotic cells in scRNA-seq data using gene expression profiles from mitotic and interphase cells.

The paper identifies widespread 3' UTR splicing in cancer, showing it regulates oncogene expression through NMD-dependent and -independent mechanisms, with specific examples in colon cancer.

This study identifies hnRNPUL1's role in Integrator-mediated snRNA cleavage and links its mutations to amyotrophic lateral sclerosis.

The paper shows that RNA export factors are co-transcriptionally recruited to mRNAs via splicing before 3-end processing, influencing splicing and polyadenylation.

CGAT-core is a Python framework for building scalable, reproducible computational biology workflows, demonstrated with an RNAseq analysis pipeline.

Alevin improves gene abundance estimation in droplet-based single-cell RNA sequencing by accurately handling UMI deduplication for both gene-unique and gene-ambiguous reads.

The paper identifies 126 proteins interacting with Cdc14 in C. albicans, revealing its role in cell cycle regulation and unexpected connections to ergosterol biosynthesis.