Author
AstraZeneca (United Kingdom)ORCID 0000-0002-7886-1367Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Abdulmohsen Alanazi, Alexander W. Cook, Isabel W. Shahid-Fuente…·Christopher P. Toseland
This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.
Noah Hitchcock, Maxine Annoh, Luigi Grassi…·Christopher P. Toseland
The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.
Ying Bai, Ivan Domenech Mercadé, Ramy Elgendy…·Rajesh K. Mistry
This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.