Christopher P. Toseland

Oncogenic ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture

This study shows ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture, supporting endocrine resistance and tumour progression.

Nuclear Myosin VI stabilises Ku-associated DNA ends during non-homologous end joining

This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.

Fluorescence cross-correlation spectroscopy quantifies affinity, cooperativity, and kinetic stability in ternary protein complexes

This paper uses FCCS to quantify affinity, cooperativity, and kinetic stability in ternary protein complexes, showing cooperative stabilization of the HER2-trastuzumab-pertuzumab complex.

DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

A Reagentless Biosensor For mRNA: A New Tool To Study Transcription

This paper introduces a reagentless mRNA fluorescent biosensor based on SSB protein, showing it is more reproducible than RT-qPCR for measuring mRNA yield.