Author

Pathricia A. Leus

Tufts UniversityORCID 0000-0002-5062-6664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Joan C. MecsasiD· 2 shared Alexsandra P. Lenhard· 1 shared Alison Ren· 1 shared Anagha Betadpur· 1 shared Anna Blumental‐PerryiD· 1 shared Brandon J. MarzulloiD· 1 shared Claudia M Manan Mejias· 1 shared D. SykesiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Joan C. MecsasORCID

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2 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedOct 6, 2026

Neutrophil degranulation and extracellular ROS production are inactivated by Yersinia pseudotuberculosis YopE through a SKAP2 independent pathway

Pathricia A. Leus, Claudia M Manan Mejias, Alison Ren…·Joan C. Mecsas

This study identifies how Yersinia pseudotuberculosis uses YopE and YopH to inhibit neutrophil degranulation and ROS production through distinct pathways.

DOI 10.1128/mbio.01984-26

humanproteomics

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ImmunologyAging CellPeer-reviewedMar 1, 2026

Host aging induces a senescent-like phenotype in neutrophils and altered transcriptional responses to Streptococcus pneumoniae

Michael C. Battaglia, Manmeet Bhalla, Brandon J. Marzullo…·Elsa N. Bou Ghanem

This study shows that aging leads to senescent-like neutrophils in mice, which have reduced antimicrobial function and altered transcriptional responses to Streptococcus pneumoniae.

2 citations

mousebulk RNA-seq

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