Author

Alexsandra P. Lenhard

University at Buffalo, State University of New York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Elsa N. Bou GhanemiD· 3 shared Manmeet BhallaiD· 2 shared Michael C. BattagliaiD· 2 shared Shaunna R. SimmonsiD· 2 shared Anagha Betadpur· 1 shared Anna Blumental‐PerryiD· 1 shared Brandon J. MarzulloiD· 1 shared Bruce A. DavidsoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

Elsa N. Bou GhanemORCID

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3 papers

Recent·Most cited

CD73 controls neutrophil responsiveness to type I interferon impairing antibacterial responses during secondary pneumococcal pneumonia

Alexsandra P. Lenhard, Chloe Picciano, Miles J Stefko, Shaunna R. Simmons, Manmeet Bhalla, Bruce A. Davidson, Elsa N. Bou Ghanem

This study identifies CD73 as a regulator of neutrophil responsiveness to type I interferon, which impairs antibacterial responses during secondary pneumococcal pneumonia following influenza A virus infection.

bioRxiv · Aug 19, 2026 · PreprintImmunology

Host aging induces a senescent-like phenotype in neutrophils and altered transcriptional responses to Streptococcus pneumoniae

Michael C. Battaglia, Manmeet Bhalla, Brandon J. Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat Can Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron, Lee Ann Garrett‐Sinha, Joan C. Mecsas, Anna Blumental‐Perry, Elsa N. Bou Ghanem

This study shows that aging leads to senescent-like neutrophils in mice, which have reduced antimicrobial function and altered transcriptional responses to Streptococcus pneumoniae.

Aging Cell · Mar 1, 2026Peer-reviewedImmunology

Adenosine 2B receptor signaling impairs vaccine-mediated protection against pneumococcal infection in young hosts by blunting neutrophil killing of antibody opsonized bacteria

Shaunna R. Simmons, Alexsandra P. Lenhard, Michael C. Battaglia, Elsa N. Bou Ghanem

This study shows that adenosine 2B receptor signaling impairs neutrophil killing of antibody-opsonized pneumococci in young vaccinated mice, reducing vaccine efficacy, but not in aged mice.

Vaccines · Apr 15, 2025Peer-reviewedImmunology