Host aging induces a senescent-like phenotype in neutrophils and altered transcriptional responses to Streptococcus pneumoniae
Michael C. Battaglia, Manmeet Bhalla, Brandon J. Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat Can Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron, Lee Ann Garrett‐Sinha, Joan C. Mecsas, Anna Blumental‐Perry, Elsa N. Bou Ghanem
This study shows that aging leads to senescent-like neutrophils in mice, which have reduced antimicrobial function and altered transcriptional responses to Streptococcus pneumoniae.
Aging Cell · Mar 1, 2026Peer-reviewedImmunology