Ruth Rincón-Heredia

This study investigates how antidepressants interact with LPA3 receptors through functional assays and docking simulations, revealing distinct effects on calcium and ERK 1/2 signaling.

The paper identifies two distinct agonist binding cavities in the LPA3 receptor through docking and functional studies, showing differential ligand interactions and mutation sensitivity.

The paper compares the pharmacodynamic effects of LPA and OMPT on LPA3 receptors, revealing differences in signaling, internalization, and refractory states, suggesting the existence of two binding sites.

This study shows that astrocytic extracellular vesicles can accelerate spontaneous recovery after stroke in rats by promoting anatomical and functional recovery.