María Teresa Romero‐Ávila

Antidepressants interact with an LPA3 receptor binding site: functional and docking studies

This study investigates how antidepressants interact with LPA3 receptors through functional assays and docking simulations, revealing distinct effects on calcium and ERK 1/2 signaling.

Multiple LPA3 receptor agonist binding sites evidenced under docking and functional studies

The paper identifies two distinct agonist binding cavities in the LPA3 receptor through docking and functional studies, showing differential ligand interactions and mutation sensitivity.

LPA3: Pharmacodynamic differences between lysophosphatidic acid and oleoyl-methoxy glycerophosphothionate. Biased agonism, two sites.

The paper compares the pharmacodynamic effects of LPA and OMPT on LPA3 receptors, revealing differences in signaling, internalization, and refractory states, suggesting the existence of two binding sites.