The paper identifies grey matter microstructural changes in Lewy body diseases using diffusion MRI metrics, finding increased tODI and FWF linked to cognitive impairment and p-tau217 levels.

bioRxiv · Jan 7, 2026 · PreprintNeuroscience

Evidence for divergent cortical organisation in Parkinsons disease and Lewy Body Dementia

Angeliki Zarkali, George E. C. Thomas, Naomi Hannaway, Ivelina Dobreva, Melissa Grant‐Peters, Martina F. Callaghan, Mina Ryten, Rimona Sharon Weil

The paper uses neuroimaging to compare structural and functional connectivity gradients in Parkinson's disease with normal cognition and Lewy body dementia, finding divergent patterns associated with cognitive impairment.

Nature Communications · Nov 25, 2025Peer-reviewedNeuroscience

A molecular map of the living human brain from quantitative MRI

Melissa Grant‐Peters, George E. C. Thomas, Daan van Kruining, Louise A Huuki-Myers, Ruth Zhang, Jonathan Brenton, Hemanth R. Nelvagal, Angeliki Zarkali, James R Evans, Christina E. Toomey, Aine Fairbrother-Browne, Ivelina Dobreva, Kelsey D Montgomery, Joanne Lachica, Naomi Hannaway, , Mina Ryten

This paper introduces a non-invasive imaging framework combining qMRI and SRT to infer molecular features in neurodegeneration.

bioRxiv · Sep 24, 2025 · PreprintNeuroscience

Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes

Naomi Hannaway, Angeliki Zarkali, Rohan Bhome, Ivelina Dobreva, George E. C. Thomas, Elena Veleva, Irene Gorostiaga Belio, Katie Tucker, Amanda Heslegrave, Henrik Zetterberg, Rimona Sharon Weil

The paper compares neuroimaging and plasma biomarkers in Lewy body dementia subtypes, finding differences in white matter integrity and plasma markers between dementia with Lewy bodies and Parkinson's disease dementia.

Alzheimer s & Dementia · May 1, 2025Peer-reviewedNeuroscience

Impaired glymphatic clearance independently contributes to poor outcomes in Parkinsons disease

Angeliki Zarkali, George E. C. Thomas, Ross W. Paterson, Naomi Hannaway, Ivelina Dobreva, Amanda Heslegrave, Elena Veleva, Henrik Zetterberg, Rimona Sharon Weil

The paper shows impaired glymphatic clearance is linked to poor outcomes in Parkinson's disease, with distinct effects on brain structure and iron distribution.

bioRxiv · Jan 15, 2025 · PreprintNeuroscience

Neuroimaging and plasma marker evidence for white matter macrostructure loss in Parkinsons disease

Angeliki Zarkali, Naomi Hannaway, Peter McColgan, Amanda Heslegrave, Elena Veleva, Rhiannon Laban, Henrik Zetterberg, Andrew John Lees, Nick C. Fox, Rimona Sharon Weil

The paper shows that white matter macrostructure loss and elevated plasma neurofilament light chain levels are associated with poor outcomes in Parkinson's disease.

bioRxiv · Sep 22, 2023 · PreprintNeuroscience

Changes in both top-down and bottom-up effective connectivity drive visual hallucinations in Parkinson's disease

George E. C. Thomas, Peter Zeidman, Tajwar Sultana, Angeliki Zarkali, Adeel Razi, Rimona Sharon Weil

This study uses spectral dynamic causal modelling to show that visual hallucinations in Parkinson's disease are linked to reduced bottom-up and increased top-down effective connectivity in the visual network.

Brain Communications · Dec 14, 2022Peer-reviewedNeuroscience

Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease

Angeliki Zarkali, Andrea I. Luppi, Emmanuel Andreas Stamatakis, Suzanne Reeves, Peter McColgan, Louise‐Ann Leyland, Andrew John Lees, Rimona Sharon Weil

The paper examines dynamic brain state transitions in Parkinson's disease patients with visual hallucinations, finding altered temporal dynamics and links to neurotransmitter systems.

Communications Biology · Sep 8, 2022Peer-reviewedNeuroscience

Visual dysfunction predicts cognitive impairment and white matter degeneration in Parkinson's disease

Angeliki Zarkali, Peter McColgan, Louise‐Ann Leyland, Andrew John Lees, Rimona Sharon Weil

The paper shows that visual dysfunction in Parkinson's disease is linked to cognitive decline and white matter damage over time.

Movement Disorders · Jan 9, 2021Peer-reviewedNeuroscience