Andrew John Lees

Neuroimaging and plasma marker evidence for white matter macrostructure loss in Parkinsons disease

The paper shows that white matter macrostructure loss and elevated plasma neurofilament light chain levels are associated with poor outcomes in Parkinson's disease.

Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease

The paper examines dynamic brain state transitions in Parkinson's disease patients with visual hallucinations, finding altered temporal dynamics and links to neurotransmitter systems.

Visual dysfunction predicts cognitive impairment and white matter degeneration in Parkinson's disease

The paper shows that visual dysfunction in Parkinson's disease is linked to cognitive decline and white matter damage over time.

Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank

The paper investigates environmental and genetic risk factors for Parkinson's disease using UK Biobank data, showing gene-environment interactions and improved prediction with polygenic risk scores.

Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy

The paper identifies common LRRK2 locus variation associated with survival in progressive supranuclear palsy, linking it to gene expression regulation and suggesting therapeutic implications for tauopathies.

The BRadykinesia Akinesia INcoordination (BRAIN) tap test: capturing the sequence effect

The paper introduces a new parameter, VS, to detect bradykinesia in Parkinson's disease patients using the BRAIN tap test and validates its reliability across different hardware platforms.

Screening performance of abbreviated versions of the UPSIT smell test

The paper evaluates abbreviated versions of the UPSIT smell test to detect hyposmia, finding that a 4-item test outperforms existing shorter versions in sensitivity and specificity.

Heritability and genetic variance of dementia with Lewy bodies

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

Variation at the TRIM11 locus modifies Progressive Supranuclear Palsy phenotype

This study identifies a genetic variant at the TRIM11 locus associated with Progressive Supranuclear Palsy phenotype through GWAS and validates it in independent cohorts.