Author

Charley Schaefer

University of LeedsORCID 0000-0002-6925-0185Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Jamieson A. L. HowardiD· 2 shared Mark C. LeakeiD· 2 shared Aisha H. SyedaiD· 1 shared Alex L. Payne-DwyeriD· 1 shared Benjamin D. EngeliD· 1 shared Clément DégutiD· 1 shared Fan BaiiD· 1 shared Gaurav Kumar· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Jamieson A. L. HowardORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Sticker number modulates pyrenoid condensate assembly to support algal fitness

Gaurav Kumar, James Barrett, Philippe Van der Stappen, Alex L. Payne-Dwyer, Onyou Nam, Jack W Shepherd, Lewis Frame, Jamieson A. L. Howard, Vuk Malis, Clément Dégut, Michael R. Hodgkinson, Ralf P. Richter, Charley Schaefer, Michael J. Plevin, Maria Hondele, , Luke C. M. Mackinder

This study shows that varying the number of binding motifs in a disordered protein affects pyrenoid assembly and algal fitness.

bioRxiv · Jan 29, 2026 · PreprintCell Biology

Aggresomes protect mRNA under stress in Escherichia coli

Linsen Pei, Yujia Xian, Xiaodan Yan, Charley Schaefer, Aisha H. Syeda, Jamieson A. L. Howard, Wei Yan Zhang, Hebin Liao, Fan Bai, Mark C. Leake, Yingying Pu

The paper shows that aggresomes in E. coli store mRNA under stress, aiding rapid recovery by protecting mRNA from degradation and facilitating translation reactivation.

Nature Microbiology · Aug 19, 2025Peer-reviewedBiophysics

Sticker-and-Linker Model for Amyloid BetaCondensation and Fibrillation

Jack P. Connor, Steven D. Quinn, Charley Schaefer

This study develops a molecular model to investigate how hydrophobicity drives amyloid beta aggregation, showing that A{beta}1-42 enrichment in plaques is due to hydrophobic interactions promoting phase separation.

bioRxiv · Jun 4, 2022 · PreprintNeuroscience