ImmunologybioRxivPreprint
H5N1 influenza binding and cell entry via human class II MHC, and blocking by cross-reactive antibodies
Taylor A. Pursell, Artem I. Mikelov, Oliver Fabian Wirz…·Scott Dexter Boyd
This study shows H5N1 clade 2.3.4.4b viruses bind human MHC-II HLA-DR for cell entry, independent of sialic acid, and identifies host genetic and antibody factors that modulate this interaction.
DOI 10.64898/2026.07.22.739677