Scott Dexter Boyd

This study shows H5N1 clade 2.3.4.4b viruses bind human MHC-II HLA-DR for cell entry, independent of sialic acid, and identifies host genetic and antibody factors that modulate this interaction.

The paper identifies a disrupted CCR5-like immunoglobulin gene in black-footed ferrets linked to increased susceptibility to plague caused by Yersinia pestis.

BenchRep-T evaluates nine T-cell repertoire methods across four tasks, finding simple baselines competitive with complex models and no single method dominates all tasks.

This paper identifies covalent cyclic peptide inhibitors targeting protein-protein interactions using phage display, demonstrating antiviral activity against SARS-CoV-2.

This paper introduces ImmuneCLIP, a contrastive fine-tuning method for TCR-peptide interactions, showing improved performance over existing methods in epitope ranking and binding prediction.

The paper identifies two distinct and functional immunoglobulin heavy chain loci in big brown bats, revealing a novel mechanism for humoral immunity potentially linked to viral resistance.

The paper shows that genetic variation in the immunoglobulin heavy chain locus influences the diversity and characteristics of the human antibody repertoire.

This paper uses a mouse lemur transcriptomic atlas to identify new genes, splice junctions, and disease-related features, highlighting their relevance to primate biology and human disease.

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.