Author

Poshen B. Chen

Agency for Science, Technology and ResearchORCID 0000-0002-5122-5192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:variant effect prediction· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aaron R. CheniD· 1 shared Bin LiiD· 1 shared Bing ReniD· 1 shared Cooper BeamaniD· 1 shared Dominik StanojevićiD· 1 shared Graham McVickeriD· 1 shared Han Kwang YangiD· 1 shared Hsiuyi V. CheniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBioinformatics

Aaron R. ChenORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintApr 23, 2026

Metaxa: A Transformer-Based Deep Learning Model for Taxonomic Classification of Long Nanopore Reads

Krešimir Friganović, Dominik Stanojević, Po-Shen Benson Chen, Mile Šikić

Metaxa is a transformer-based model for classifying long Nanopore reads, outperforming existing tools on out-of-sample data and across different sequencing chemistries.

DOI 10.64898/2026.04.20.719780

metagenomicsdeep learning

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GeneticsbioRxivPreprintAug 30, 2023

Functional characterization of gene regulatory elements and neuropsychiatric disease-associated risk loci in iPSCs and iPSC-derived neurons

Xiaoyu Yang, Ian Richard Jones, Poshen B. Chen…·Yin Shen

The paper identifies functional CREs in iPSCs and neurons and links them to neuropsychiatric disease risk variants.

10 citations

humanCRISPR screen

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BioinformaticsPLoS Computational BiologyPeer-reviewedSep 16, 2020

Discovering functional sequences with RELICS, an analysis method for tiling CRISPR screens

Patrick C. Fiaux, Hsiuyi V. Chen, Poshen B. Chen…·Graham McVicker

RELICS is a Bayesian method for analyzing tiling CRISPR screens to discover functional genomic sequences with higher resolution than existing approaches.

12 citations

CRISPR screenBayesian inference

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