Melissa Hirose Wong

This paper introduces a cyclic immunofluorescence platform using photocleavable linkers for direct antibody labeling, enabling more effective cancer phenotyping with reduced specimen damage.

This study identifies RUNX1 as a key driver of tumor-immune hybrid cell invasion and dissemination in colorectal cancer, highlighting circulating hybrid cells as a biomarker for metastasis.

The paper develops NIR fluorescent probes with improved pharmacokinetics for prostate cancer imaging, enhancing clinical workflow compatibility during surgery.

This paper evaluates contrast agents for in vivo fluorescence detection of circulating tumor cells, finding that while they show high uptake, they also label non-cancer cells, reducing specificity.

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.

The paper presents an image analysis pipeline for detecting circulating hybrid cells in immunofluorescence images with human-level accuracy using a β-VAE and SVM classifier.

The paper identifies a dual state of Bmi1-expressing intestinal stem cells that drive epithelial development and tissue regeneration through dynamic Wnt signaling.