Developmental programming of hematopoietic stem cell dormancy by evasion of Notch signaling
Patricia Herrero Molinero, Eric Cantón, María Maqueda, Cristina Ruiz‐Herguido, Arnau Iglesias, J. Roquer González, Brandon Hadland, Lluı́s Espinosa, Anna Bigas
This study identifies a developmental program for hematopoietic stem cell (HSC) dormancy established during embryogenesis through evasion of Notch signaling, revealing a mechanism for long-term regenerative potential.
bioRxiv · Jan 4, 2026 · PreprintDevelopmental Biology