Author

Trinity Cookis

University of California, BerkeleyORCID 0000-0002-5145-7508Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexandria Lydecker· 2 shared Eva NogalesiD· 2 shared Alfredo Jose Florez ArizaiD· 1 shared Ana-Florina GaliciD· 1 shared Paul Victor SaueriD· 1 shared Robert TjianiD· 1 shared Vignesh KasinathiD· 1 shared Ziyuan Chen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

Alexandria Lydecker

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2 papers

Recent·Most cited

Protein cofactors diversify PRC2 architecture and function

Trinity Cookis, Ana-Florina Galic, Ziyuan Chen, Alexandria Lydecker, Alfredo Jose Florez Ariza, Robert Tjian, Eva Nogales

This study reports cryo-EM structures of PRC2.1 complexes with different cofactors, revealing how they diversify function while maintaining conserved catalytic mechanisms.

bioRxiv · Oct 26, 2026 · PreprintBiophysics

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications

Trinity Cookis, Alexandria Lydecker, Paul Victor Sauer, Vignesh Kasinath, Eva Nogales

The paper reveals how H3K4me3 and H3K36me3 inhibit PRC2 activity by blocking its interaction with chromatin and allosteric activators, using cryo-EM.

Nature Structural & Molecular Biology · Jan 7, 2025Peer-reviewedBiochemistry