Author

Alexandria Lydecker

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander E. Brady· 1 shared Alfredo Jose Florez ArizaiD· 1 shared Ana-Florina GaliciD· 1 shared Brian D. RuddiD· 1 shared Dongwen WuiD· 1 shared Elliott J. Purser· 1 shared Eva NogalesiD· 1 shared Hannah Fisk· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alexander E. Brady

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Author profile →

2 papers

Recent·Most cited

Protein cofactors diversify PRC2 architecture and function

Trinity Cookis, Ana-Florina Galic, Ziyuan Chen, Alexandria Lydecker, Alfredo Jose Florez Ariza, Robert Tjian, Eva Nogales

This study reports cryo-EM structures of PRC2.1 complexes with different cofactors, revealing how they diversify function while maintaining conserved catalytic mechanisms.

bioRxiv · Oct 26, 2026 · PreprintBiophysics

Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors

Alexander E. Brady, Shankar K. Revu, Dongwen Wu, Hannah Fisk, Khadija Kone, Alexandria Lydecker, Elliott J. Purser, Norah L. Smith, Zachary T. Hilt, Sarah Woodyear, Sarah Caddy, Sébastien Gingras, Brian D. Rudd, Mandy J. McGeachy

A single amino acid substitution in CD28 enhances signaling, leading to increased CD8 activation and Tpex generation during viral infection, while accelerating exhaustion in chronic infection.

bioRxiv · Mar 10, 2025 · PreprintImmunology