Author

Paul S. Humphries

Reset TherapeuticsORCID 0000-0002-5148-7360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Alex Laihsu· 2 shared Jessica D. SuniD· 2 shared Nikki KimuraiD· 2 shared Pamela SantiagoiD· 2 shared Ross Bersot· 2 shared Sarah W. Wurts· 2 shared Akihiro YamanakaiD· 1 shared Bruce F. O’HaraiD· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 34 mutual co-author links

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2 shared papersNeuroscience

Alex Laihsu

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2 papers

Recent·Most cited

Rapid, noninvasive, and unsupervised detection of sleep/wake using piezoelectric monitoring for pharmacological studies in narcoleptic mice

Sarah W. Wurts, Jessica D. Sun, Alex Laihsu, Nikki Kimura, Pamela Santiago, Kevin D. Donohue, Bruce F. O’Hara, Ross Bersot, Paul S. Humphries

This paper introduces PiezoSleep, a noninvasive method to detect sleep/wake in narcoleptic mice, showing it can identify phenotypes and screen drugs efficiently.

bioRxiv · Sep 25, 2018 · PreprintNeuroscience

Partial ablation of the orexin field induces a sub narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration

Sarah W. Wurts, Jessica D. Sun, Pamela Santiago, Alex Laihsu, Nikki Kimura, Akihiro Yamanaka, Ross Bersot, Paul S. Humphries

This study shows that partial orexin neuron loss in mice leads to a sub-narcoleptic phenotype with compensatory wake-promotion, resembling narcolepsy type 2.

SLEEP · May 31, 2018Peer-reviewedNeuroscience