Akihiro Yamanaka

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

This paper identifies a preoptic circuit involving Crh-expressing neurons that initiates rewarming from torpor in mice and shows similar activation in hibernators.

This study investigates how optogenetic manipulation of DRN serotonergic neurons affects motor actions and waiting behavior in mice during reward tasks, finding distinct effects on sustained actions versus stationary waiting.

This study shows that psychosocial stress alters feeding behavior patterns in mice through disruptions in the mesolimbic dopamine system, suggesting these patterns could serve as biomarkers for stress and neuropsychiatric disorders.

This study identifies neural mechanisms for uninstructed orofacial movements during reward-based learning in mice, showing distinct roles of dopamine and motor cortex circuits.

This study identifies neural circuits in the hypothalamus that regulate torpor by mapping torpor-activated neurons and analyzing their connectivity.

This paper shows that dopamine responses shift backward in time during associative learning, aligning with TD prediction error models.

This study compares the development of narcoleptic symptoms in male and female orexin-tTA; TetO-DTA mice, finding females develop symptoms faster but both sexes show similar symptoms by week 6.

This paper demonstrates the use of X-ray-induced scintillation to remotely control neural function in mice, achieving bidirectional modulation of behavior through optogenetic activation and inhibition.

This study shows that ablating both orexin and MCH neurons in mice leads to increased wakefulness, reduced sleep, and more severe cataplexy compared to ablating orexin neurons alone.

This study shows orexin signaling in GABAergic lateral habenula neurons promotes aggression and conditioned place preference, suggesting a potential therapeutic target for reducing aggressive behaviors.

This study uses orexin-Flp knock-in mice to distinguish orexin-dependent and -independent functions of orexin neurons, finding orexin is essential for sustained arousal and basic neuronal properties.

This study identifies VTAGad67+ GABAergic neurons as key regulators of NREM sleep in mice through chemogenetic and optogenetic manipulations and electrophysiological recordings.

This study shows that D1 and D2 neurons in the anteromedial olfactory tubercle of mice have opposing roles in mediating attractive and aversive behaviors during place preference tests.

This study shows that partial orexin neuron loss in mice leads to a sub-narcoleptic phenotype with compensatory wake-promotion, resembling narcolepsy type 2.