Hande Karahan

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Network analysis reveals strain-dependent response to misfolded tau aggregates

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer 's disease

This study examines postmortem brains of AsymAD cases to identify mechanisms of cognitive resilience, finding enhanced microglial dynamics and reduced tau seeding in the amyloid plaque microenvironment.