Author

Mario Zierden

University of CologneORCID 0000-0002-5169-751XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Eva Maria BerghauseniD· 1 shared Holger WinkelsiD· 1 shared Joachim HerziD· 1 shared Marius VantleriD· 1 shared Michelle D. TallquistiD· 1 shared Moritz SchwabiD· 1 shared Norbert GerdesiD· 1 shared Stephan Ernst BaldusiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Eva Maria BerghausenORCID

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1 paper

Recent·Most cited

An Apoptotic Failsafe Program Involving PDGF-dependent PI 3-Kinase Activity Contributes to Plaque Composition in Atherosclerosis

Marius Vantler, Eva Maria Berghausen, Moritz Schwab, Mario Zierden, Wolfram‐Hubertus Zimmermann, Norbert Gerdes, Michelle D. Tallquist, Joachim Herz, Holger Winkels, Stephan Ernst Baldus, Stephan Rosenkranz

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

bioRxiv · Oct 28, 2026 · PreprintBiochemistry