Wolfram‐Hubertus Zimmermann

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

This study shows that geometric confinement and substrate stiffness influence cardiomyocyte force generation differently, with confinement enhancing contractile stress and relaxation on physiological substrates.

This study shows that cardiac sarcomeres exhibit stochastic heterogeneity and dynamic instability, which enable robust contraction despite mechanical constraints.

This paper presents a correlative imaging platform combining fluorescence microscopy and scanning SAXS to study cellular structures in native conditions, showing agreement between label-free SAXS and labeled fluorescence data.

This study shows that peroxisome dysfunction in mice and engineered human myocardium leads to heart failure through metabolic impairment and disrupted cellular respiration.

SarcAsM provides a multiscale analysis tool for sarcomere structure and dynamics in cardiomyocytes using deep learning and graph-based methods.