Author

Kayvan R. Keshari

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-5181-8035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:imaging· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:dimensionality reduction· 1 Assay:metabolomics· 1

Frequent Co-Authors

Albert P. CheniD· 2 shared Biranavan UthayakumariD· 2 shared Charles H. CunninghamiD· 2 shared Chris HeyniD· 2 shared Hany SolimaniD· 2 shared Nadia D. BragagnoloiD· 2 shared Nathan Ma· 2 shared Nicole I. C. CappellettoiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Albert P. ChenORCID

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Author profile →

4 papers

Recent·Most cited

Co-Hyperpolarized Dehydroascorbate and Pyruvate MRI Predicts Treatment Response in Glioblastoma

Elizabeth Coffee, Paola Porcari, Saket Patel, Grace Figlioli, Marjan Berishaj, Ingo K. Mellinghoff, Kayvan R. Keshari

This study uses co-hyperpolarized MRI to predict treatment response in glioblastoma by measuring oxidative stress and glycolytic flux.

bioRxiv · Nov 11, 2025 · PreprintCancer Biology

Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging

Huiyong Cheng, Dawson Miller, Nneka Southwell, Paola Porcari, Joshua L. Fischer, Isobel Taylor, J. Michael Salbaum, Claudia Kappen, Fenghua Hu, Cha Yang, Kayvan R. Keshari, Steven S. Gross, Marilena D’Aurelio, Qiuying Chen

The paper develops an R package for pixel-by-pixel ratio imaging of metabolite pairs in mass spectrometry imaging, enhancing spatial contrast and revealing new tissue regions and biomarkers.

eLife · Mar 18, 2025Peer-reviewedBioinformatics

Task Activation Results in Regional 13C-Lactate Signal Increase in the Human Brain

Biranavan Uthayakumar, Nicole I. C. Cappelletto, Nadia D. Bragagnolo, Albert P. Chen, Nathan Ma, William J. Perks, Ruby Endre, Fred Tam, Simon J. Graham, Chris Heyn, Kayvan R. Keshari, Hany Soliman, Charles H. Cunningham

The paper uses HP-13C MRI to show increased 13C-lactate signal in brain regions activated during a visual task compared to a control condition.

Journal of Cerebral Blood Flow & Metabolism · Jan 25, 2025Peer-reviewedNeuroscience

Evidence of Lactate Shuttling in the Human Brain using Hyperpolarized 13C-MRI

Biranavan Uthayakumar, Hany Soliman, Albert P. Chen, Nadia D. Bragagnolo, Nicole I. C. Cappelletto, Ruby Endre, William J. Perks, Nathan Ma, Chris Heyn, Kayvan R. Keshari, Charles H. Cunningham

The paper tests lactate shuttling in the human brain using hyperpolarized 13C-MRI and finds that reducing lactate saturation increases bicarbonate signal, indicating lactate conversion to pyruvate and oxidation.

Magnetic Resonance in Medicine · Jan 17, 2024Peer-reviewedNeuroscience