Maria Ormhøj

Antigen-scaffolds loaded with hyper-stable Neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

This study shows that Ag-Neo2/15 scaffolds expand antigen-specific T cells with enhanced cytotoxicity and reduced dysfunctionality compared to Ag-IL2/21 scaffolds.

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

This paper introduces T-Expand, a dextran-based nanoparticle system for T cell expansion that enhances CAR T cell efficacy and reduces manufacturing complexity.

Engineered yeast cells simulating CD19+ cancers to control CAR T cell activation

The paper presents a yeast-based system to simulate CD19+ cancers for controlled CAR T cell activation and evaluates antigen density effects.

Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells

This study develops antigen-scaffold technology to expand CAR and TCR T cells with improved functionality and efficacy.

Development of antigen-dextramers for detection and evaluation of CAR T cells

This paper develops antigen-dextramers to stain and functionally assess CAR T cells, showing they enable both detection and activation analysis with adjustable antigen density.

De novo designed pMHC binders facilitate T cell induced killing of cancer cells

This paper designs de novo pMHC binders using generative models to create T cell-based cancer therapeutics with high specificity and minimal cross-reactivity.