María García-Alai

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

This study shows that clathrin adaptors Ent5 and Sla2 undergo liquid-liquid phase separation, with distinct structural features driving condensate formation and function in endocytosis and trafficking.

This study quantifies the binding affinities of TRPM2 domains for ADPR analogs and shows that MHR1/2 drives activation while NUDT9H maintains structural integrity.

The paper studies seasonal changes in a modern microbialite reef, finding that environmental fluctuations drive microbial community shifts and mineralization patterns, indicating metabolic drivers over taxonomy in carbonate precipitation.

The paper analyzes microbial biosynthetic potential across geothermal environments, finding that tectonic settings influence the diversity and types of biosynthetic gene clusters.

The paper identifies two CLC binding sites on Sla2 and shows Pan1 competes with CLC for a conserved site, revealing divergence in endocytic mechanisms between fungi and metazoa.

ChiraKit is an online tool that processes and analyzes circular dichroism data to calculate secondary structure, estimate helicity, fit unfolding models, and decompose spectra.

The paper investigates clathrin binding selectivity among yeast adaptor proteins, finding Ent5 has the highest affinity and Ent1 shows stronger clathrin interaction than Ent2.

The paper determines the cryo-EM structures of two amphibian antimicrobial peptides, revealing cross-β amyloid fibrils and their structural polymorphism.