Lucas A. Defelipe

This study shows that clathrin adaptors Ent5 and Sla2 undergo liquid-liquid phase separation, with distinct structural features driving condensate formation and function in endocytosis and trafficking.

This study quantifies the binding affinities of TRPM2 domains for ADPR analogs and shows that MHR1/2 drives activation while NUDT9H maintains structural integrity.

The paper identifies two CLC binding sites on Sla2 and shows Pan1 competes with CLC for a conserved site, revealing divergence in endocytic mechanisms between fungi and metazoa.

ChiraKit is an online tool that processes and analyzes circular dichroism data to calculate secondary structure, estimate helicity, fit unfolding models, and decompose spectra.

The paper investigates clathrin binding selectivity among yeast adaptor proteins, finding Ent5 has the highest affinity and Ent1 shows stronger clathrin interaction than Ent2.