Author

Christopher J. Knowlton

Louisiana State UniversityORCID 0000-0002-5202-7374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:electronic health records· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Carmen C. CanavieriD· 4 shared Jochen RoeperiD· 3 shared Marle Jahnke· 2 shared Strahinja StojanoviciD· 2 shared Bernd FakleriD· 1 shared Carol M UpchurchiD· 1 shared Dorothea SchulteiD· 1 shared Jochen SchwenkiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Carmen C. CanavierORCID

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4 papers

Recent·Most cited

Slow Dynamics Differentially Determine the Robustness of Regular Pacemaking: Distinct Subpopulations of Midbrain Dopamine Neurons Illustrate the Principle

Christopher J. Knowlton, Strahinja Stojanovic, Marle Jahnke, Jochen Roeper, Carmen C. Canavier

The paper models midbrain dopamine neuron subpopulations to show how slow dynamics enhance robustness of regular pacemaking against noise.

bioRxiv · Aug 18, 2026 · PreprintNeuroscience

Nullcline Analysis Provides Dynamic Mechanisms for the Differences in Electrical Activity of Distinct Subpopulations of Midbrain Dopamine Neurons

Christopher J Knowlton, Strahinja Stojanovic, Marle Jahnke, Jochen Roeper, Carmen C Canavier

The paper uses nullcline analysis to explain how differences in electrical activity between subpopulations of midbrain dopamine neurons arise from variations in Kv4 channel dynamics and AHP strength.

bioRxiv · Feb 4, 2026 · PreprintNeuroscience

Persistent Interruption in Parvalbumin Positive Inhibitory Interneurons: Biophysical and Mathematical Mechanisms

Carol M Upchurch, Christopher J. Knowlton, Simon Chamberland, Carmen C. Canavier

The paper investigates the biophysical and mathematical mechanisms of persistent firing interruption in parvalbumin-expressing interneurons, showing how Kv1 channel inactivation enables robust persistent silencing.

eNeuro · Jun 17, 2024Peer-reviewedNeuroscience

A biophysical regulator of inhibitory integration and learning in mesolimbic dopamine neurons

Kauê Machado Costa, Niklas Hammer, Christopher J. Knowlton, Jochen Schwenk, Tamara Müller, Dorothea Schulte, Bernd Fakler, Carmen C. Canavier, Jochen Roeper

The paper identifies KChIP4a as a biophysical regulator that selectively affects inhibitory integration and learning in dopamine neurons projecting to the nucleus accumbens core.

bioRxiv · Aug 24, 2022 · PreprintNeuroscience