Simon Chamberland

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

This study shows dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons through specific interneuron subtypes and voltage-gated calcium channels.

This study shows CBD reduces high-frequency hippocampal activity by modulating inhibitory circuits, specifically enhancing PV-INs and reducing SST-INs.

The paper investigates the biophysical and mathematical mechanisms of persistent firing interruption in parvalbumin-expressing interneurons, showing how Kv1 channel inactivation enables robust persistent silencing.

The paper identifies functional subtypes of hippocampal somatostatin-expressing interneurons using transcriptomic features and transgenic mouse models.

The paper shows that brief synaptic inhibition can persistently silence fast-spiking interneurons for hundreds of milliseconds, impacting circuit function through disinhibition of pyramidal cells.

This study investigates how CBD modulates LPI-GPR55 signaling at excitatory and inhibitory synapses, showing its role in reducing seizure activity by blocking LPI's pro-excitatory effects and enhancing inhibitory synaptic strength.

This study shows Fxr1 is downregulated during synaptic scaling and sleep deprivation, linking it to homeostatic plasticity and sleep regulation.

The paper identifies synaptic mechanisms controlling VIP-expressing interneurons' firing and their recruitment during theta oscillations and ripples in the hippocampus.

This paper introduces an improved voltage indicator and imaging method to enable high-speed, high-resolution voltage imaging in deeply located neurons of awake mice.

The paper identifies a novel type of VIP+ neuron in the mouse hippocampus that projects to both CA1 and subiculum, showing distinct molecular and functional properties.

The paper demonstrates that mossy fibers count action potentials to transmit information to CA3 pyramidal neurons through presynaptic calcium dynamics and vesicle replenishment.