Kauê Machado Costa

Characterization of nucleus accumbens dopamine dynamics during positive and negative operant reinforcement in rats

This study examines dopamine dynamics in the nucleus accumbens during positive and negative reinforcement in rats, finding distinct patterns for different reinforcer types and availability.

Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity

The paper shows that surviving DA SN neurons after lesion recovery exhibit full in vivo firing range through Kv4.3-mediated pacemaker plasticity.

Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states

The paper examines dopamine and acetylcholine correlations in the nucleus accumbens during a behavioral task in rats, finding their relationship varies based on task phases.

Sequential recruitment of accumbal dopamine and acetylcholine during learning

This study investigates how dopamine and acetylcholine dynamics change during learning in rats, finding that acetylcholine signals evolve sequentially and complement dopamine in determining learning content and rate.

Generalized cue reactivity in dopamine neurons after opioids

This study investigates cue reactivity in dopamine neurons after opioids, finding that drug and natural reward cues elicit similar enhanced responses, challenging existing hypotheses about dopamine's role in relapse.

Striatal dopamine release reflects a domain-general prediction error

This study shows dopamine signals prediction errors during both latent learning of value-neutral cues and reward-based conditioning, suggesting a domain-general role in model-based learning.

Schema cell formation in orbitofrontal cortex is suppressed by hippocampal output

This study investigates how hippocampal output affects schema formation in orbitofrontal cortex, finding that inactivation during learning accelerates schema correlates while post-learning inactivation has no effect, supporting a parallel model of cognitive map formation.

The role of the orbitofrontal cortex in creating cognitive maps

The paper investigates the role of the orbitofrontal cortex in creating cognitive maps by showing that its inactivation disrupts specific cue-outcome associations but not model-based learning overall.

A biophysical regulator of inhibitory integration and learning in mesolimbic dopamine neurons

The paper identifies KChIP4a as a biophysical regulator that selectively affects inhibitory integration and learning in dopamine neurons projecting to the nucleus accumbens core.

In vivo functional diversity of midbrain dopamine neurons within identified axonal projections

This study maps the in vivo firing patterns of midbrain dopamine neurons based on their axonal projections, revealing functional diversity that challenges classical anatomical boundaries.