Jochen Roeper

The paper models midbrain dopamine neuron subpopulations to show how slow dynamics enhance robustness of regular pacemaking against noise.

The paper uses nullcline analysis to explain how differences in electrical activity between subpopulations of midbrain dopamine neurons arise from variations in Kv4 channel dynamics and AHP strength.

The paper identifies a conserved voltage-dependent pacemaker current essential for slow firing in neurons and cardiac cells, confirmed by models and experiments.

The paper shows that surviving DA SN neurons after lesion recovery exhibit full in vivo firing range through Kv4.3-mediated pacemaker plasticity.

The paper identifies KChIP4a as a biophysical regulator that selectively affects inhibitory integration and learning in dopamine neurons projecting to the nucleus accumbens core.

The paper shows lactate enhances cortical neuron spiking activity through KATP channels and is preferentially used as an energy substrate over glucose.

This study shows that HCN-channel dysfunction in neural progenitors causes microcephaly by disrupting cell cycle progression and proliferation in mice.

The paper identifies an unconventional conductance essential for pacemaking in nigral dopamine neurons using pharmacological evidence and electrophysiological analysis.

This study identifies a Kv4 channelopathy in mouse vagal motoneurons caused by α-synuclein overexpression, leading to impaired gastrointestinal motility as a non-motor prodromal symptom of Parkinson's disease.

This study identifies subthreshold membrane potential events in midbrain dopamine neurons in vivo, revealing two biophysical mechanisms that generate distinct firing patterns related to prediction error signaling.

The paper shows neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo, both under pathological and physiological conditions.

The paper shows that α-synuclein aggregates disrupt pacemaking in vulnerable nigrostriatal dopamine neurons via K-ATP channels, contributing to Parkinson's disease pathogenesis.

This study maps the in vivo firing patterns of midbrain dopamine neurons based on their axonal projections, revealing functional diversity that challenges classical anatomical boundaries.