Cancer BiologyEMBO Molecular MedicinePeer-reviewed
TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
Jelle Verhoeven, Kathryn Jacobs, Francesca Rizzollo…·Patrizia Agostinis
This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.