Jean‐Christophe Marine

This study maps the heterogeneity of human melanoma metastases across brain, liver, and lung using single-nucleus RNA sequencing, revealing organ-specific immune and stromal adaptations.

This study identifies castration-tolerant Club-like cells in prostate cancer and shows that targeting FOSL1/AP-1 and PIM kinases reduces their progenitor properties and tumor growth.

This study shows that IFNγ suppresses lymphatic vessel growth and metastasis by altering metabolism and immune function in melanoma.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

This paper introduces Gtag&T-seq, a low-cost single-cell multi-omics method that reveals cell state plasticity and treatment response in melanoma subclones.

This study shows that varying levels of oncogenic KRAS drive different cell states and metastatic progression in lung adenocarcinoma, with implications for treatment.

SPArrOW is a pipeline for spatial transcriptomics analysis that improves data quality, provides visual quality checks, and enables interactive exploration and optimization of processing parameters.

The paper develops software to infer copy number and detect single nucleotide variants in spatial transcriptomics data, applied to skin cancer to reveal genetic patterns and clonal populations.

The paper uses deep learning to analyze enhancer logic across species in melanoma, identifying conserved regulatory complexes and their roles.

The paper identifies an intermediate cell state in melanoma through single-cell RNA-seq and ATAC-seq, revealing a gene regulatory network that governs phenotype switching and potential therapeutic targets.

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.

This study investigates the dynamics of X-chromosome reactivation during mouse iPSC reprogramming, revealing hierarchical gene activation patterns and the role of chromatin regulators.

Building gene regulatory networks from scRNA-seq and clustering cells on them identifies stable states robustly to batch effects, applied to mouse and human brain and to melanoma.