Takehiko Yokomizo

This study identifies PLCXD2 as a phosphatidylinositol-preferring phospholipase that maintains retinal lipid homeostasis and photoreceptor integrity.

This study determines the cryo-EM structure of GPR30 with bicarbonate ions, identifies key residues for activation, and provides insights into G-protein coupling and drug development.

This study identifies LAMP2B as a mediator of microlipophagy, showing its role in preventing obesity and related metabolic disorders through enhanced lipid hydrolysis.

The paper identifies dysregulated expanded endocannabinoid system metabolites in ALS and shows FAAH inhibition improves motor neuron degeneration in models.

The paper identifies a mechanism by which FTY720 reduces MS-like disease in an animal model through B12-TCN2-CD320 signaling in astrocytes.