Patrick Lagüe

The hydrophobicity of peptides limits their availability to bind to interacting domains

The paper identifies that peptide hydrophobicity affects their availability in yeast cells, impacting synthetic interaction strength beyond in vitro measurements.

Amino Acid Insertion Energetics in a POPC Bilayer from Unbiased Molecular Dynamics

The paper quantifies amino acid side-chain insertion energetics in a POPC bilayer using unbiased molecular dynamics simulations and derives potentials of mean force to characterize bilayer partitioning.

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae

The paper identifies key residues in Fks hotspots that confer echinocandin resistance in Saccharomyces cerevisiae using molecular dynamics and deep-mutational scanning.

Branch-Enabling N-Methyltransferase in Golgi Reconciles Divergent Models of Galanthamine Biosynthesis

This study identifies LaTMT2 as a Golgi-localized N-methyltransferase that resolves competing models of galanthamine biosynthesis and provides a target for metabolic engineering.

CRISPR-induced deletion with SaCas9 restores dystrophin expression in dystrophic models in vitro and in vivo.

This study demonstrates that SaCas9-mediated deletion restores dystrophin expression in DMD patient-derived myoblasts and in vivo in a mouse model.