Pascale Lemieux

The hydrophobicity of peptides limits their availability to bind to interacting domains

The paper identifies that peptide hydrophobicity affects their availability in yeast cells, impacting synthetic interaction strength beyond in vitro measurements.

A protein-fragment complementation assay to quantify synthetic protein scaffold efficiency

The paper introduces a protein-fragment complementation assay to evaluate scaffold efficiency in yeast and identifies key factors affecting it.

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

The paper shows that mutations in protein binding domains, combined with regulatory divergence, determine the fate of gene duplicates in a protein interaction network.

Toeholder: a software for automated design and in silico validation of toehold riboswitches

Toeholder is a software tool for automated design and in silico validation of toehold riboswitches, incorporating experimental data and molecular dynamics simulations.