Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells
Louis P. Widom, Panteha Torabian, Michelle A. Trempel, Molly C. McCloskey, Lea Vacca Michel, James L. McGrath, Thomas R. Gaborski
The paper shows that bacterial extracellular vesicles disrupt a BBB on-chip model indirectly via immune cell activation, not directly through BMEC damage.
Lab on a Chip · Jan 1, 2026Peer-reviewedCell Biology