Author

Louis P. Widom

Rochester Institute of TechnologyORCID 0000-0002-2492-9004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:spatial transcriptomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Thomas R. GaborskiiD· 3 shared James L. McGrathiD· 2 shared Lea Vacca MicheliD· 2 shared Michelle A. TrempeliD· 2 shared Panteha TorabianiD· 2 shared Abigail C Wojehowski· 1 shared Alexis M. FeidleriD· 1 shared Britta EngelhardtiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Thomas R. GaborskiORCID

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3 papers

Recent·Most cited

Cell BiologyLab on a ChipPeer-reviewedJan 1, 2026

Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells

Louis P. Widom, Panteha Torabian, Michelle A. Trempel…·Thomas R. Gaborski

The paper shows that bacterial extracellular vesicles disrupt a BBB on-chip model indirectly via immune cell activation, not directly through BMEC damage.

1 citation

humanspatial transcriptomics

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BioengineeringMaterials Today BioPeer-reviewedSep 27, 2025

Pericytes Repair Engineered Defects in the Basement Membrane to Restore Barrier Integrity in an in vitro Model of the Blood-Brain Barrier.

Michelle A. Trempel, Yimei Du, Louis P. Widom…·James L. McGrath

7 citations

spatial transcriptomicsimaging

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Cell BiologybioRxivPreprintMay 12, 2025

Antibiotic treatment modulates Escherichia coli-derived bacterial extracellular vesicle (BEV) production and their capacity to upregulate ICAM-1 in human endothelial cells

Louis P. Widom, Panteha Torabian, Abigail C Wojehowski…·Thomas R. Gaborski

This study shows antibiotic treatment affects BEV production and their ability to upregulate ICAM-1 in endothelial cells, with meropenem increasing BEV production and stimulatory capacity in E. coli strains.

2 citations

E. coliexperimental assay

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