James L. McGrath

Design and Application of a μSiM Outer Blood-Retinal Barrier (OBRB) Model as a Drug Development Tool

The paper develops a μSiM-OBRB model to measure drug transport across the outer blood-retinal barrier, showing drug permeability and disease-relevant phenotypes.

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugs

This paper develops a human synovial tendon-on-a-chip model to study peritendinous adhesions and test anti-fibrotic drugs, showing IL-6 inhibition reduces fibrosis and adhesion formation.

Dynamics of Neutrophilia at the Neurovascular Unit Arising from Repeated Pulmonary Inflammation

This study investigates how repeated pulmonary inflammation leads to neutrophil dynamics at the neurovascular unit, showing increased neutrophilia and microglial activation in the brain.

Modular Integration of Impedance Sensing for Real-Time Assessment of Barrier Integrity

This paper introduces a modular system for real-time assessment of barrier integrity using impedance sensing in microphysiological systems.

Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells

The paper shows that bacterial extracellular vesicles disrupt a BBB on-chip model indirectly via immune cell activation, not directly through BMEC damage.

Catch-and-Display Immunoassay for Digital Biomarker Detection

This paper introduces a cost-effective digital immunoassay called CAD-IA for detecting low-abundance biomarkers, demonstrating its sensitivity and linearity using the TBI biomarker S100B.

Vitamin D differentially modulates effector and regulatory T-cell migration across the blood-brain barrier

This study shows that vitamin D reduces effector T-cell migration across the blood-brain barrier while preserving regulatory T-cell entry, potentially benefiting multiple sclerosis patients.

Pericytes Repair Engineered Defects in the Basement Membrane to Restore Barrier Integrity in an in vitro Model of the Blood-Brain Barrier.

Fluid Flow Impacts Endothelial-Monocyte Interactions in a Model of Vascular Inflammatory Fibrosis

This study shows that adding physiological flow to a human tendon-on-a-chip model increases endothelial activation and monocyte infiltration, highlighting the role of flow in immune cell interactions during inflammation.

Rapid Assessment of Biomarkers on Single Extracellular Vesicles Using 'Catch and Display' on Ultrathin Nanoporous Silicon Nitride Membranes

This paper introduces CAD-LB, a microfluidic technique for rapid EV biomarker assessment, validated on nanoparticles, purified EVs, and clinical plasma samples.