Thomas R. Gaborski

Targeting Fibrotic Scars with Extracellular Vesicles Extracted from Mature Aloe vera Gel: Enhanced Antioxidant, Anti-inflammatory, and Antifibrotic Activity through M2 Macrophage Polarization and Inhibition of Myofibroblast Differentiation

This study isolates and characterizes extracellular vesicles from Aloe vera gel, showing that mature manually extracted vesicles have superior antioxidant, anti-inflammatory, and antifibrotic effects.

Development of a PEGylated Parylene Nanopocket Membrane for the Capture and Release of Lipid Vesicles

This paper develops a PEGylated nanopocket membrane for size-selective capture and release of lipid vesicles and extracellular vesicles, demonstrating its effectiveness in separating particles of different sizes.

Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells

The paper shows that bacterial extracellular vesicles disrupt a BBB on-chip model indirectly via immune cell activation, not directly through BMEC damage.

Pericytes Repair Engineered Defects in the Basement Membrane to Restore Barrier Integrity in an in vitro Model of the Blood-Brain Barrier.

Orthogonal and Robust Analytics Enable Reproducible and Scalable Manufacturing of High Purity Extracellular Vesicles Derived from Mesenchymal Stromal Cells

This paper develops an analytical toolbox and scalable downstream processing workflow for high purity extracellular vesicles from mesenchymal stromal cells, using orthogonal methods to improve reproducibility and purity.

Antibiotic treatment modulates Escherichia coli-derived bacterial extracellular vesicle (BEV) production and their capacity to upregulate ICAM-1 in human endothelial cells

This study shows antibiotic treatment affects BEV production and their ability to upregulate ICAM-1 in endothelial cells, with meropenem increasing BEV production and stimulatory capacity in E. coli strains.