Sebastiano Pasqualato

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

This study uses cryo-EM to reveal how microtubule association induces an Mg-free apo-like ADP pre-release conformation in kinesin-1, independent of tail interactions.

This study determines the structures of MCT8 and MCT10 in different states to elucidate the molecular mechanism of thyroid hormone transport and explain disease-related mutations.