Author

Kenny Roose

Ghent UniversityORCID 0000-0002-5270-4603Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Organism:rat· 1 Organism:yeast· 1

Frequent Co-Authors

Nico CallewaertiD· 3 shared Sandrine VanmarckeiD· 3 shared Bert SchepensiD· 2 shared Chiara LonigroiD· 2 shared Daria FijałkowskaiD· 2 shared Dirk JochmansiD· 2 shared Hannah EeckhautiD· 2 shared Iebe RosseyiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Nico CallewaertORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 14, 2025

ENGINEERING AND PRECLINICAL EVALUATION OF DRIED FOOD-FORMULATED YEAST-SECRETED ANTIBODIES AS PERI-EXPOSURE PROPHYLAXIS AGAINST CLOSTRIDIOIDES DIFFICILE DISEASE.

Charlotte Roels, Marlies Ballegeer, Semiramis Yılmaz…·Nico Callewaert

This study develops and tests dried food-formulated yeast-secreted VHH antibodies as prophylaxis against Clostridioides difficile disease in mice, showing high efficacy in preventing mortality and disease.

DOI 10.1101/2025.11.14.688569

mouseexperimental assay

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MicrobiologybioRxivPreprintMar 4, 2024

Yeast-based production platform for potent and stable heavy chain-only antibodies

Chiara Lonigro, Hannah Eeckhaut, Royan Alipour Symakani…·Nico Callewaert

This paper presents a yeast-based platform for producing stable and potent heavy chain-only antibodies, demonstrating its effectiveness with an anti-SARS-CoV-2 example.

DOI 10.1101/2024.03.04.580093

yeastprotein sequence

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Molecular BiologybioRxivPreprintMar 8, 2021

Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents

Bert Schepens, Loes van Schie, Wim Nerinckx…·Xavier Saelens

The paper describes the development of a broadly neutralizing antibody, XVR011, effective against SARS-CoV-2 and its variants in animal models.

7 citations

mouserat

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