Daria Fijałkowska

This study investigates combining dexamethasone with PPAR agonist GW7647 to improve glucocorticoid efficacy and reduce metabolic side effects in rheumatoid arthritis models.

The paper assesses MS-based identifications of unannotated human microproteins, finding large variation in reported proteins and PSM quality across studies.

This study shows that targeting PPAR and ERR receptors reduces liver fat, fibrosis, and inflammation in MASLD models, suggesting a new therapeutic strategy.

The paper evaluates the antigenic evolution of N1 neuraminidase in H1N1 influenza viruses from 2009 to 2020, identifying key mutations driving antigenic changes and their impact on antibody neutralization.

The paper identifies crosstalk between ERRalpha and PPARalpha transcription factors, showing ERRalpha can act as both a repressor and activator of PPARalpha-mediated gene expression.

This paper presents a yeast-based platform for producing stable and potent heavy chain-only antibodies, demonstrating its effectiveness with an anti-SARS-CoV-2 example.

The paper investigates N-terminal proteoforms and finds they can engage in different protein complexes compared to their canonical counterparts.

The paper develops an open-source yeast chassis, OPENPichia, for synthetic biology by reverse engineering and characterizing industrial Pichia strains.

The paper investigates non-coding transcript translation in HEK293T cells, finding limited but potentially functional translation products using ribosome profiling and mass spectrometry.

The paper describes the development of a broadly neutralizing antibody, XVR011, effective against SARS-CoV-2 and its variants in animal models.

The paper analyzes 3'UTR changes during neuronal differentiation and in ASD, finding longer 3UTRs in ASD patients and a role for CPEB4 and APLP1 in APA regulation.