Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Nilanjan Ghosh Dastidar, Nicola S. Freyer, Valentyn Petrychenko, Ana C. de A. P. Schwarzer, Bee‐Zen Peng, Ekaterina Samatova, Christina Kothe, Marlen Schmidt, Frank Peske, Antonio Zaccaria Politi, Henning Urlaub, Niels Fischer, Marina V. Rodnina, Ingo Wohlgemuth
The paper identifies a novel antibiotic resistance mechanism where fusA mutations slow ribosome movement when aminoglycosides are bound, preventing error cluster formation and maintaining bacterial growth.
Nature Communications · Oct 29, 2025Peer-reviewedMolecular Biology